I am seeking employment in clinical or laboratory research where I can utilize my education and expertise. Ideally, I would like to secure a position in infectious diseases, immunology or oncology research. Presently, I can travel and take additional courses if necessary. If you would like to discuss my resume, please contact me by phone after 4pm or e-mail..
Maureen Maher
5233 Shelter Creek Lane
San Bruno, CA
EDUCATION
New York University, Graduate School of Arts and Sciences, Dept of Biology, NY, NY
M.S. Biology; June 1988 (focus: molecular and cell biology) 9/86 - 6/88
Rutgers University, Cook College and University College, New Brunswick, NJ
B.S. Biology, June 1982 (focus: microbiology) 9/76 -6/82 (part-time student)
TECHNICAL KNOWLEDGE
Taqman Assays, Western, Northern, and Southern Blots; Chromatography; RT-PCR,PCR; Automated DNA sequencing; site- directed mutagenesis; cDNA Cloning; Subcloning; Construction of recombinant genes in various expression vectors; radioisotopes; 2-hybrid library screening, in vitro transcription / translation assays; in situ immunoflourescence; CAT assays; B-galactosidase assays; Immunoprecipitation and protein binding assays; ELISA's; Hybridomas; Agar-diffusion bioassay development; T-cell purification and proliferation assays;; in vivo (rats) and in vitro analysis of antifungal agents; Mammalian tissue culture; Protein expression in Pichia, bacteria and mammalian cells; small scale production, purification and evaluation of proteins. Computer skills: Microsoft Word, Excel, MacVector, Gene Construction kit
PUBLICATIONS
Taremi, S., Beyer, B., Maher, M., Yao, N., Prosise, W., Weber, P., Malcolm, B.. Construction, expression, and characterization of a novel fully activated recombinant single-chain hepatitis C virus protease. Protein Science (1998), 7: 2143-2149
Kim, A., Maher, M., Hayman, J., Ozer, J., Zerby, D., Yates, J., Lieberman, P..
An imperfect correlation between DNA replication activity of Epstein-Barr virus nuclear antigen 1 (EBNA 1) and binding to the nuclear import receptor, RCH1/importin a.
Virology 239, 340-351 (1997)
Maher, M., Cong, F., Kindelberger, D., Nasmyth, K., Dalton, S.. Cell Cycle-regulated transcription of the CLB2 gene is dependent on MCM1 and a ternary complex factor. Molecular and Cellular Biology, June; 15 (6); 3129-3137. (1995)
Coleman,T.A., Kunsch, C., Maher, M., Ruben, S.M., Rosen, C.A.. Acquisition of NFKB1-selective DNA binding by substitution of four amino acid residues from NFKB1 into RelA. Molecular and Cellular Biology, July; 13 (7); 3850-9. (1993)
Ruben, S. M., Klement, J. F., Coleman, T. A., Maher, M., Chen, C.H., Rosen, C.A..
I-Rel: A novel Rel-related protein that inhibits NF-kappa B transcriptional activity.
Genes and Development, May; 6 (5); 745-60. (1992)
Ruben, S. M., Dillon, P.J., Schreck, R., Henkel, T., Chen, C.H., Maher, M., Baeuerle, P.A., Rosen,C.A.. Isolation of a Rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B. Science, March 22, vol. 251, 1490-1493. (1991)
Umetsu, D.T., Katzen, D., Chatila, T., Miller, R., Jabara, H., Maher, M., Oettgen, H., Terhorst, C., Geha, R.S.. Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3. Clinical Immunology and Immunopathology, vol. 43, 1987
Bernard, E., Donnelly, H.S., Maher, M., Armstrong, D.. Use of a new bioassay to study pentamidine pharmacokinetics. Journal of Infectious Diseases, vol. 152, 750-754. (1985
Depaolis, A., Maher, M., Katz, S., Rosen, J.. Tissue distribution of C14-sulfamethazine residues in swine. Journal of Food Safety, vol. 2, 119-129.(1980)
PROFESSIONAL EXPERIENCE
San Francisco Unified School District
555 Franklin Street
Substitute teacher
9/02-present
The Buddy System Tutors
Biology and Chemistry tutor
9/02-present
San Mateo Union High School District
650 North Delaware St.
San Mateo, CA 94401
Substitute teacher
10/01-present
Roche Biosciences, Palo Alto, CA
Research Associate
Research Focus: Target evaluation via antisense technology.
10/00-3/01
UCSF, San Francisco, CA
Research Associate II
Research Focus: Gene constructs for mouse knock-outs.
3/00-8/00
Wyeth-Lederle Vaccines and Pediatrics, Pearl River, NY
Research Focus: Construction and analysis of viral vectors for vaccine research.
Wyeth-Ayerst Research, Oncology/Immunology, Pearl River, NY
Research Focus: Cloning growth factors; generating and expressing chimeric molecules.
Research Associate II
6/98-7/99
Schering-Plough Research Institute, Kenilworth, NJ
Research Focus: Generating and analyzing mutations in HCV proteins.
Research Associate
7/97-5/98
Novartis Pharmaceuticals Corporation, East Hanover, NJ
Research Focus: Cloning, expression, purification and analysis of proteins.
Research Associate B
2/96-3/97
Roche Institute of Molecular Biology, Nutley, NJ
Research Focus: Mechanisms of gene regulation with emphasis on NF-Kappa B;
Cell Cycle regulation of transcription in yeast; Epstein -Barr Virus replication proteins.
Research Associate
11/90-12/95
New York University, NY, NY
Graduate School of Arts and Sciences (MS program)
Lab Instructor ?TA (Zoology, Physiology, Anatomy)
9/86-6/88
The Children's Hospital, Boston, MA
Research Focus: T cell proliferation; The etiology of Kawasaki disease; IgE regulation
Research Technician II
1/85- 8/86
Memorial Sloan-Kettering Cancer Center, NY, NY
Research Focus: The diagnosis and treatment of systemic mycosis in the immuno-compromised host; Development of an agar-diffusion bioassay to measure pentamidine in serum, urine and tissues.
Research Technologist
6/82- 8/84
Rutgers University, Cook College, New Brunswick, NJ Research Focus: Sulfamethazine metabolism in swine; toxicity analysis of parenteral oils. Research Technician 9/78-8/79 (full -time); 9/79-2/81 (part-time during the semesters, full-time in the summers)
References available upon request.
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